Aminotransferases analysis in patients with dengue serotype IV

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Felício Stenio Schuenck Rozete
Mariana Brasileiro Vieira Puppo
João Tadeu Damian Souto Filho
José Ramos Glória
Luiz José de Souza

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OBJECTIVE: To evaluate the aminotransferase levels in patients with dengue serotype IV. METHODS: We conducted a cross-sectional analysis of 3,596 people with laboratoryconfirmed dengue. RESULTS: The analysis showed that 49.2% (1,768) had normal aminotransferase levels, 43.4% (1,559) had changes in levels by up to three times the upper limit of normal, 7.0% (253) had elevations three times the reference value and 0.4% (16) developed acute hepatitis. Patients with thrombocytopenia and hemoconcentration had major changes in the levels of enzymes (p<0.05). Women were more susceptible to those changes than men (p<0,05). The average AST and ALT were higher in dengue hemorrhagic type (147.51±137.74U/L and 111.54±81.27U/L) as compared to dengue fever (55.18±52.06U/L and 60.39±57.50U/L) (p<0.05). Leukopenic patients had aminotransferases average lower compared to individuals without any drop in overall white blood cell count (p<0.05). A total of 224 patients were submitted to hospitalization, with the AST average of 88.18±100.47U/L and ALT 77.95±88.38U/L, which is higher than the average in ambulatory patients (p<0.05). CONCLUSION: A significant number of patients was found with altered levels of enzymes, which requires clinical laboratory monitoring for an extended period.

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